# Product Engine

> Discover Peptone's Product Engine, combining ensemble biology, experimental physics, AI, computation, and translation to generate small-molecule drug candidates.

[View this page on Peptone](https://peptone.io/technology/)

Experimental evidence and computation in one discovery loop

We measure disordered proteins in motion, resolve the shapes they move through, and design small-molecule drug candidates against transient pockets.

## Measurement, modeling, design, and validation in one Product Engine

- Each stage of discovery hands the next one evidence rather than assumption. Measurement reads a disordered protein directly in solution, enhanced sampling resolves the rare states where a binding pocket opens, and generative models propose molecules against those states, with the laboratory testing every prediction.
- That closed loop makes disordered targets tractable. There is no fixed structure to lock onto, so experiment and computation share one evidence layer and stay in step, from the first measurement to a candidate at the bench.

## What holds true across every program

The same commitments carry from the first measurement to the molecule we test in the laboratory.

- Measured in solution, not forced into a crystal
- Described as ensembles, not single structures
- Rare binding-competent states resolved, not averaged away
- Designs treated as hypotheses, tested at the bench
- One shared evidence layer across experiment and computation
- Proprietary ensemble and assay data that compounds across programs

## Product Engine capabilities

- [Measurement](/technology/hdx-ms.md) - Ultra-fast hydrogen-deuterium exchange reads disordered proteins in solution and catches the transient structure that appears in milliseconds.
- [Modeling](/technology/modeling.md) - Experimentally constrained ensembles reveal the rare states and transient pockets that static structures cannot resolve.
- [Design](/technology/generative-ai.md) - Multiple AI models explore sourceable chemistry against transient pockets in rare disordered-protein states, with matched HDX-MS closing the experimental loop.
- [Validation](/technology/translational.md) - How Peptone's Bellinzona BSL2 laboratory returns protein, assay, and live-cell evidence to each new design.